NAFDAC is informing healthcare professionals and the public of a report received concerning emerging evidence showing an increased risk of drug poisoning when gabapentinoids (gabapentin and pregabalin) are used together with certain medicines, particularly opioids and benzodiazepines.A study conducted by researchers at University College London (UCL) found that among patients taking gabapentinoids, concomitant use of benzodiazepines was associated with approximately a two-fold increase in the risk of hospitalisation for drug poisoning, while concurrent use with opioids increased the risk by about 30%.Gabapentinoids are commonly prescribed for neuropathic pain, epilepsy, and anxiety disorders and are increasingly used as alternatives to opioids for pain management. Risk Information
The risk may be higher in:

• Elderly patients
• Patients with respiratory disorders
• Patients receiving opioids, benzodiazepines, or other CNS depressants
• Patients with a history of substance abuse.

Possible adverse effects include:

• Excessive drowsiness
• Respiratory depression
• Impaired consciousness
• Drug poisoning.

Advice to the Public

Seek immediate medical attention if you experience unusual drowsiness, difficulty breathing, or loss of consciousness while taking these medicines.

Use gabapentin and pregabalin only as prescribed by a healthcare professional

Inform your healthcare provider of all medicines you are taking.

Avoid self-medication and unauthorised medicine combinations.

Healthcare professionals and consumers are advised to report any suspicion of the sale of substandard and falsified medicines or medical devices to the nearest NAFDAC office, call 0800-162-3322, or send an email to sf.alert@nafdac.gov.ng